A Biochemical Analysis of Detrimental Effects of COVID-19 Severity on Multiple Organ Systems



Covid-19, Biochemical Tests, Kidney Disease, Lung Damage, C-reactive protein (CRP).


To understand the impact of the COVID-19 pandemic on multiple organ system research and review is required. While the primary symptoms of COVID-19 are respiratory distress and lung injury. This study investigates liver and kidney involvement and blood parameter changes among different groups of patients. Understanding these changes is crucial because COVID-19-induced liver and renal injuries, can complicate medication dosing and increase the risk of severe drug reactions. Despite the abundance of literature on COVID-19, information is lacking regarding the prevalence and clinical significance of liver injury, renal injury, and CBC alterations in COVID-19 patients from regions with low mortality and severity rates. This study aims to report and characterize changes in these parameters during the disease, and assess the relationship between them in a cohort of 354 confirmed COVID-19 patients (198 males and 156 females) in Lahore. Chi-square and T-test were used to evaluate the hypothesis. Several parameters showed significant changes, including the RBC count in normal patients, PLT levels in normal patients, ALT levels in normal, moderate, and severe patients, AST level in moderate patients, and Creatinine amount in moderate COVID-19 patients. These results highlight COVID-19's systemic impact on these parameters, enhancing our understanding of disease severity and progression. Furthermore, this knowledge guides clinical management, aiding in the prevention of severe illness and the reduction of serious health issues like renal failure and liver damage.


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How to Cite

Umar, M., Tahir, M., & Shabbir, C. A. (2023). A Biochemical Analysis of Detrimental Effects of COVID-19 Severity on Multiple Organ Systems. TSF Journal of Biology , 1(2), 28–45. Retrieved from https://tsfjb.com/ojs/index.php/tsfjb/article/view/15